Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 8, Issue 8, Pages 603-612Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm2216
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Funding
- Wellcome Trust Funding Source: Medline
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There are numerous ways that endocytic cargo molecules may be internalized from the surface of eukaryotic cells. In addition to the classical clathrin- dependent mechanism of endocytosis, several pathways that do not use a clathrin coat are emerging. These pathways transport a diverse array of cargoes and are sometimes hijacked by bacteria and viruses to gain access to the host cell. Here, we review our current understanding of various clathrinin-dependent mechanisms of endocytosis and propose a classification scheme to help organize the data in this complex and evolving field.
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