Journal
NATURE REVIEWS IMMUNOLOGY
Volume 7, Issue 8, Pages 645-650Publisher
NATURE RESEARCH
DOI: 10.1038/nri2136
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Funding
- NIDDK NIH HHS [R01 DK59658] Funding Source: Medline
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In 1997, the autoimmune regulator (AIRE) gene was identified as the locus underlying susceptibility to the polyendocrine autoimmune disease known as autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED). In the intervening 10 years, it has become increasingly clear that this rare disorder has provided us with an illuminative window on one of the most fundamental processes of the immune system - the establishment and maintenance of self tolerance.
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