Journal
CURRENT OPINION IN CHEMICAL BIOLOGY
Volume 11, Issue 4, Pages 388-393Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.cbpa.2007.07.006
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Funding
- NIBIB NIH HHS [R01 EB000244-27, R37 EB000244, R01 EB000244] Funding Source: Medline
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It has become increasingly clear that both soluble factors, such as growth factors, and insoluble factors, including the surfaces on which cells grow, can have controlling effects on stem cell behavior and differentiation. While much progress has been made in biomaterial design and application, the rational design of biomaterial cues to direct stem cell behavior and differentiation remains challenging. Recent advances in automated, high-throughput methods for synthesizing and screening combinatorial biomaterial libraries and cellular microenvironments promise to accelerate the discovery of factors that control stem cell behavior. Specific examples include miniaturized, automated, combinatorial material synthesis and extracellular matrix screening methods as well microarrayed methods for creating local microenvironments of soluble factors, such as small molecules, siRNA, and other signaling molecules.
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