Journal
PROTEOMICS CLINICAL APPLICATIONS
Volume 1, Issue 8, Pages 792-804Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/prca.200700043
Keywords
biomarker; body fluids; mass spectrometry; urine
Funding
- NCRR NIH HHS [M01 RR000032-43, M01 RR000032] Funding Source: Medline
- NIDDK NIH HHS [P01 DK061525, R01 DK047322-06, R24 DK064400, R24 DK064400-01, P01 DK061525-01, R01 DK071802-02, R01 DK071802, R01 DK047322] Funding Source: Medline
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All organisms contain thousands of proteins and peptides in their body fluids. A deeper insight into the functional relevance of these polypeptides under different physiological and pathophysiological conditions and the discovery of specific peptide biomarkers would greatly enhance diagnosis and therapy of specific diseases. The low-molecular-weight proteome, also termed peptidome, provides a rich source of information. Due to its unique features, the technical challenges differ somewhat from those in common proteomics. In this paper, we focus on the lowmolecular-weight urinary proteome. We review the methodological aspects of sample collection, preparation, analysis, and subsequent data evaluation. In the second part of this review, we summarize the recent progress in the definition and identification of clinically relevant polypeptide markers.
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