Journal
CURRENT OPINION IN NEUROBIOLOGY
Volume 17, Issue 4, Pages 490-497Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.conb.2007.07.014
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Funding
- NIDCR NIH HHS [DE016927, R01 DE016927, R01 DE016927-01A1, R01 DE016927-02] Funding Source: Medline
- NINDS NIH HHS [R01 NS046303, R01 NS049104-03, R01 NS046303-01A1, NS046303, NS049104, R01 NS049104, R01 NS049104-01A1, R01 NS049104-02, R01 NS046303-03, R01 NS046303-04, R01 NS046303-02] Funding Source: Medline
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Six highly temperature-sensitive ion channels of the transient receptor potential (TRP) family have been implicated to mediate temperature sensation. These channels, expressed in sensory neurons innervating the skin or the skin itself, are active at specific temperatures ranging from noxious cold to burning heat. In addition to temperature sensation thermoTRPs are the receptors of a growing number of environmental chemicals (chemesthesis). Recent studies have provided some striking new insights into the molecular mechanism of thermal and chemical activation of these biological thermometers.
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