Journal
JOURNAL OF BACTERIOLOGY
Volume 189, Issue 16, Pages 6074-6079Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JB.00349-07
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Funding
- Wellcome Trust Funding Source: Medline
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A novel and functional conjugative transfer system identified in 0119:H2 enteropathogenic Escherichia coli (EPEC) strain MB80 by subtractive hybridization is encoded on a large multidrug resistance plasmid, distinct from the well-described EPEC adherence factor (EAF) plasmid. Variants of the MB80 conjugative resistance plasmid were identified in other EPEC strains, including the prototypical 0111:NM strain B171, from which the EAF plasmid has been sequenced. This separate large plasmid and the selective advantage that it confers in the antibiotic era have been overlooked because it comigrates with the virulence plasmid on conventional gels.
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