Journal
JOURNAL OF CELL SCIENCE
Volume 120, Issue 15, Pages 2507-2516Publisher
COMPANY OF BIOLOGISTS LTD
DOI: 10.1242/jcs.003590
Keywords
Boolean networks; Src family kinases; axonal growth; neurotrophic factors
Categories
Ask authors/readers for more resources
Integration of multiple inputs from the extracellular environment, such as extracellular matrix molecules and growth factors, is a crucial process for cell function and information processing in multicellular organisms. Here we demonstrate that co-stimulation of dorsal root ganglion neurons with neurotrophic factors ( NTFs)-glial-cell-line-derived neurotrophic factor, neurturin or nerve growth factor-and laminin leads to axonal growth that requires activation of Src family kinases ( SFKs). A different, SFK-independent signaling pathway evokes axonal growth on laminin in the absence of the NTFs. By contrast, axonal branching is regulated by SFKs both in the presence and in the absence of NGF. We propose and experimentally verify a Boolean model of the signaling network triggered by NTFs and laminin. Our results demonstrate that NTFs provide an environmental cue that triggers a switch between separate pathways in the cell signaling network.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available