Journal
LEUKEMIA RESEARCH
Volume 31, Issue 8, Pages 1135-1139Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.leukres.2006.11.008
Keywords
erythroleukaemia; diabetes insipidus; empty sella; TGF-beta 1; EVI-1
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We report on two cases of patients who developed diabetes insipidus (DI) before acute erythroleukaemia (EL). A brain MRI showed an empty sella turcica in one case and hypothalamo-hypophyseal peduncle damage in the second case. Reduced levels of TGF-beta 1 and Vitamin D3, with associated EVI-1 over-expression and karyotypic abnormalities were documented. These two cases show specific chromosomal/molecular alterations in EL with DI. The hypothesis of pituitary involvement in erythroleukemogenesis is discussed. (c) 2006 Elsevier Ltd. All rights reserved.
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