Journal
CHEMICAL & PHARMACEUTICAL BULLETIN
Volume 55, Issue 8, Pages 1254-1257Publisher
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/cpb.55.1254
Keywords
benzimidazole; zinc proline; water; recyclability
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Zn-proline (5 mol%) performs as a novel water-soluble and recyclable Lewis acid catalyst for the selective synthesis of 1,2-disubstituted benzimidazoles from wide range of substituted o-phenylenediamines and aldehydes in moderate to excellent isolated yields (42-92%) using water as solvent at ambient temperature.
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