Journal
CURRENT OPINION IN CELL BIOLOGY
Volume 19, Issue 4, Pages 394-401Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2007.05.001
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Funding
- Medical Research Council [MC_U122665003] Funding Source: Medline
- NEI NIH HHS [R01 EY015625-05, R01 EY015625] Funding Source: Medline
- NIAMS NIH HHS [R01 AR048155-06, R01 AR048155] Funding Source: Medline
- Medical Research Council [MC_U122665003] Funding Source: researchfish
- MRC [MC_U122665003] Funding Source: UKRI
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Some cells harbour specialised lysosome-related organelles (LROs) that share features of late endosomes/lysosomes but are functionally, morphologically and/or compositionally distinct. Ubiquitous trafficking machineries cooperate with cell type specific cargoes to produce these organelles. Several genetic diseases are caused by dysfunctional LRO formation and/or motility. Many genes affected by these diseases have been recently identified, revealing new cellular components of the trafficking machinery. Current research reveals how the products of these genes cooperate to generate LROs and how these otherwise diverse organelles are related by the mechanisms through which they form.
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