Journal
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
Volume 397, Issue 3, Pages 1203-1215Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s00216-010-3674-z
Keywords
Electrochemistry; Mass spectrometry; Biomimetic oxidation; DNA adduct; DNA oxidation; DNA damage
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Oxidation is commonly involved in the alteration of nucleic acids giving rise to diverse effects including mutation, cell death, malignancy, and aging. We demonstrate that electrochemistry represents an efficient and fast method to mimic oxidative modification of nucleic acids occurring in biological systems. Oxidation reactions were performed in a thin-layer cell employing a conductive diamond electrode as the working electrode and were monitored with electrospray ionization-mass spectrometry. Mass voltammograms were acquired for guanosine, adenosine, cytidine, and uridine. The observed oxidation potentials increased in the order guanosine << adenosine
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