Journal
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
Volume 397, Issue 4, Pages 1397-1415Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s00216-010-3481-6
Keywords
Quantum dots; In vitro; In vivo; Cytotoxicity; Doped quantum dots
Funding
- National Natural Science Foundation of China [20475020, 20075009, 20875036]
- Ministry of Science and Technology of Jilin Province, China [20080544]
- Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry [3C109M791412]
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Quantum dots (QDs), also named semiconductor nanocrystals, have initiated a new realm of bioscience by combining nanomaterials with biology, which will profoundly influence future biological and biomedical research. In this review, we describe the extraordinary optical properties of QDs and developments in methods for their synthesis. We focus on fluorescent imaging with QDs both in vitro and in vivo, and the cytotoxicity of QDs and potential barriers to their use in practical biomedical applications. Finally, we provide insights into improvements aimed at decreasing the cytotoxicity of QDs and the future outlook of QD applications in biomedical fields.
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