Journal
NATURE GENETICS
Volume 39, Issue 8, Pages 951-953Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ng2067
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Funding
- MRC [G0500070] Funding Source: UKRI
- Medical Research Council [G0500070, MC_U106179471] Funding Source: researchfish
- Medical Research Council [MC_U106179471, G0500070] Funding Source: Medline
- Wellcome Trust [077016, 068545/z/02] Funding Source: Medline
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We studied genes involved in pancreatic beta cell function and survival, identifying associations between SNPs in WFS1 and diabetes risk in UK populations that we replicated in an Ashkenazi population and in additional UK studies. In a pooled analysis comprising 9,533 cases and 11,389 controls, SNPs in WFS1 were strongly associated with diabetes risk. Rare mutations in WFS1 cause Wolfram syndrome; using a gene-centric approach, we show that variation in WFS1 also predisposes to common type 2 diabetes.
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