Journal
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
Volume 397, Issue 1, Pages 401-406Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s00216-010-3504-3
Keywords
Oxaliplatin; HPLC; ICP-MS
Funding
- Austrian Science Fund [P16089-N03]
- Austrian Science Fund (FWF) [P16089] Funding Source: Austrian Science Fund (FWF)
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A novel method for rapid HPLC-ICP-MS analysis of oxaliplatin in human urine was developed implementing a stationary HPLC phase with a particle size of 1.8 A mu m. The method allowed a cycle time of < 1 min at a HPLC flow rate of 0.9 mL min(-1). Procedural limits of detection of 0.05 A mu g L-1 oxaliplatin (150 fg on column) were obtained. Analysis of oxaliplatin in patient urine showed that accurate quantification of the intact drug demanded for storage at -80 A degrees C and rapid measurement after thawing.
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