Journal
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
Volume 394, Issue 7, Pages 1719-1727Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s00216-009-2702-3
Keywords
SERS; Protein detection; SERS-active substrate; Label-free detection; Raman dye-labeled detection
Funding
- National Natural Science Foundation of P. R. China [20573041, 20773044, 20873050]
- Program for Changjiang Scholars and Innovative Research Team in University [IRT0422]
- Program for New Century Excellent Talents in University
- 111 project [B06009]
- Development Program of the Science and Technology of Jilin Province [20060902-02]
- KAKENHI
- Ministry of Education, Culture, Sports, Science and Technology of Japan [470, 20043032]
- Grants-in-Aid for Scientific Research [20043032] Funding Source: KAKEN
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Proteins are essential components of organisms and they participate in every process within cells. The key characteristic of proteins that allows their diverse functions is their ability to bind other molecules specifically and tightly. With the development of proteomics, exploring high-efficiency detection methods for large-scale proteins is increasingly important. In recent years, rapid development of surface-enhanced Raman scattering (SERS)-based biosensors leads to the SERS realm of applications from chemical analysis to nanostructure characterization and biomedical applications. For proteins, early studies focused on investigating SERS spectra of individual proteins, and the successful design of nanoparticle probes has promoted great progress of SERS-based immunoassays. In this review we outline the development of SERS-based methods for proteins with particular focus on our proposed protein-mediated SERS-active substrates and their applications in label-free and Raman dye-labeled protein detection.
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