Journal
INTERNATIONAL JOURNAL OF ANDROLOGY
Volume 30, Issue 4, Pages 393-396Publisher
WILEY
DOI: 10.1111/j.1365-2605.2007.00796.x
Keywords
epigenetics; transgenerational; endocrine; disruptors; DNA methylation; sex; determination
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Funding
- NIEHS NIH HHS [R01 ES012974] Funding Source: Medline
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The ability of an environmental exposure (i.e. endocrine disruptor) during sex determination to reprogramme the male germline and promote an epigenetic transgenerational disease phenotype suggests that environmental factors and compounds may permanently alter the germline epigenome. This epigenetic transgenerational phenomenon will be discussed with respect to adult-onset germline disease (e.g. testicular cancer). A thorough literature review is not provided, rather a perspective is provided on how this epigenetic transgenerational toxicology should be considered in germ cell disease and testicular cancer.
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