Journal
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
Volume 396, Issue 1, Pages 421-441Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s00216-009-3172-3
Keywords
Synthetic polymers; Liquid chromatography; Two-dimensional separations; Combinations of exclusion (entropic) and interaction (enthalpic) retention mechanisms
Funding
- VEGA (Vedecka grantova agentura) [2/0171/09]
- APVV (Agentura na podporu vedy a vyskumu) [0592-07]
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Two-dimensional liquid chromatography, 2D-LC of synthetic polymers is critically assessed. Similarities and differences of 2D-LC of low-molecular-mass and polymeric substances are reviewed. The rationale of application of 2D-LC to macromolecular substances is discussed. Basic information on retention mechanisms in liquid chromatography of synthetic polymers is furnished. The principles, reasons, and significance of coupling of retention mechanisms are explained. The resulting separation processes are elucidated, and the technical concepts of the corresponding experimental arrangements are described. The benefits of 2D-LC are demonstrated together with numerous problems and shortcomings of the method.
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