Journal
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 51, Issue 8, Pages 2979-2981Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.01394-06
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Funding
- NIAID NIH HHS [1 K08 AI061149, T32 AI052080, R01 AI050438, AI28388, 5 T32 AI052080, R01 AI028388, R01 AI42159, R01 AI042159, R01 AI50438, R56 AI028388] Funding Source: Medline
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Calcineurin mutation or inhibition enhanced the antifungal morphological effect of cell wall inhibitors caspofungin or nikkomycin Z against Aspergillusfumigatus. Quantification of 1,3-beta-D-glucan revealed decreased amounts in the calcineurin A (AcnaA) mutant. Calcineurin can be an excellent adjunct therapeutic target in combination with other cell wall inhibitors against A. fumigatus.
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