Journal
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
Volume 396, Issue 1, Pages 229-240Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s00216-009-3033-0
Keywords
Quantum dots; Bioconjugation; Fluorescence; Biosensing; Biolabeling and imaging
Funding
- Fundacao para a Ciencia e a Tecnologia [SFRH/BPD/40876/2007]
- European Commission [036812]
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Quantum dots (QDs) are inorganic semiconductor nanocrystals that have unique optoelectronic properties responsible for bringing together multidisciplinary research to impel their potential bioanalytical applications. In recent years, the many remarkable optical properties of QDs have been combined with the ability to make them increasingly biocompatible and specific to the target. With this great development, QDs hold particular promise as the next generation of fluorescent probes. This review describes the developments in functionalizing QDs making use of different bioconjugation and capping approaches. The progress offered by QDs is evidenced by examples on QD-based biosensing, biolabeling, and delivery of therapeutic agents. In the near future, QD technology still faces some challenges towards the envisioned broad bioanalytical purposes.
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