Journal
NATURE NEUROSCIENCE
Volume 10, Issue 8, Pages 949-951Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nn1931
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Funding
- NIDA NIH HHS [R01 DA015718-05, R01 DA015718, DA015718] Funding Source: Medline
- NIDCD NIH HHS [T32 DC000054, T32-DC00054] Funding Source: Medline
- NINDS NIH HHS [T32 NS007375, T32-NS07375] Funding Source: Medline
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Addicts and drug-experienced animals have decision-making deficits in reversal-learning tasks and more complex 'gambling' variants. Here we show evidence that these deficits are mediated by persistent encoding of outdated associative information in the basolateral amygdala. Cue-selective neurons in the basolateral amygdala, recorded in cocaine-treated rats, failed to change cue preference during reversal learning. Further, the presence of these neurons was critical to the expression of the reversal-learning deficit in the cocaine-treated rats.
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