Journal
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
Volume 394, Issue 2, Pages 481-488Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s00216-009-2721-0
Keywords
Biomolecular assembly; Nanobiosensor; Evanescent-field-coupled waveguide; SiO2; Aptamer
Funding
- Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan
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Biological self-assembly is a natural process that involves various biomolecules, and finding the missing partner in these interactions is crucial for a specific biological function. Previously, we showed that evanescent-field-coupled waveguide-mode sensor in conjunction with a SiO2 waveguide, the surfaces which contain cylindrical nanometric holes produced by atomic bombardment, allowed us to detect efficiently the biomolecular interactions. In the present studies, we showed that the assembly of biomolecules can be monitored using the evanescent-field-coupled waveguide-mode biosensor and thus provide a methodology in monitoring assembly process in macromolecular machines while they are assembling.
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