Journal
NATURAL PRODUCT RESEARCH
Volume 21, Issue 10, Pages 889-896Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786410601129606
Keywords
antibacterial activity; extraction and isolation; structural elucidation
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Arctotis arctotoides is a perennial herb used medicinally for the treatment or various ailments in the Eastern Cape, South Africa. Different extracts of the plant were investigated for their antim crobial constituents. This led to the isolation and identification of a new daucosterol derivative 3-O-[beta- D-(6'-nonadeanoate)glucopyranosyl]-beta-sitosterol and seven known compounds namely: serratagenic acid, stigmasterol, daucosterol, zaluzanin D, dehydrocostus-lactone, nepetin, and pedalitin. The structures of the compounds were elucidated on the basis of spectral analysis, including homo and hetero nuclear correlation NMR experiments (COSY, NOESY, HMQC, HMBC) and mass spectra as well as by comparison with available data in the literature. The compounds exhibited antibacterial activity except stigmasterol, daucosterol and dehydrocostuslactone. Nepetin was the most active against Bacillus subtilis and Staphylococcus aureus with the minimum inhibitory concentrations of 4 mu g mL(-1) and 31 mu g mL(-1), respectively, while others exhibited moderate activity.
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