Journal
JOURNAL OF LEUKOCYTE BIOLOGY
Volume 82, Issue 2, Pages 282-285Publisher
WILEY
DOI: 10.1189/jlb.1206752
Keywords
toll-like receptors; systemic inflammatory response syndrome; heparan sulfate
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Funding
- NIAID NIH HHS [AI53733] Funding Source: Medline
- NIGMS NIH HHS [GM069922] Funding Source: Medline
- PHS HHS [HHL079067] Funding Source: Medline
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TLRs are usually thought to recognize substances produced by microorganisms and thus, to initiate host defenses. This concept, however, fails to explain some functions of this family of receptors. Recognition of endogenous substances may explain the broader functions of TLRs in physiology and disease. Activation of TLRs by endogenous substances necessitates vigorous control of the function of the receptors. This communication will summarize a line of research, which points to an endogenous agonist for TLR4 and a putative mechanism for controlling the function of that receptor.
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