Journal
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
Volume 394, Issue 1, Pages 235-244Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s00216-009-2666-3
Keywords
Ion mobility; Ion mobility-mass spectrometry; Mass spectrometry; Collision cross section; Conformation space; Oligonucleotides; Carbohydrates; Peptides; Lipids
Funding
- Direct For Mathematical & Physical Scien
- Division Of Chemistry [0850976] Funding Source: National Science Foundation
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The conformation space occupied by different classes of biomolecules measured by ion mobility-mass spectrometry (IM-MS) is described for utility in the characterization of complex biological samples. Although the qualitative separation of different classes of biomolecules on the basis of structure or collision cross section is known, there is relatively little quantitative cross-section information available for species apart from peptides. In this report, collision cross sections are measured for a large suite of biologically salient species, including oligonucleotides (n=96), carbohydrates (n=192), and lipids (n=53), which are compared to reported values for peptides (n=610). In general, signals for each class are highly correlated, and at a given mass, these correlations result in predicted collision cross sections that increase in the order oligonucleotides
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