Journal
CARBON
Volume 45, Issue 9, Pages 1891-1898Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.carbon.2007.04.021
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Funding
- NIEHS NIH HHS [T32 ES007060-29, P30 ES003850-22, T32 ES007060, P30 ES003850] Funding Source: Medline
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There is a pressing need to develop rapid whole animal-based testing assays to assess the potential toxicity of engineered nanomaterials. To meet this challenge, the embryonic zebrafish model was employed to determine the toxicity of fullerenes. Embryonic zebrafish were exposed to graded concentrations of fullerenes [C-60, C-70, and C-60(OH)(24)] during early embryogenesis and the resulting morphological and cellular responses were defined. Exposure to 200 mu g/L C-60 and C-70 induced a significant increased in malformations, pericardial edema, and mortality; while the response to C-60(OH)(24) exposure was less pronounced at concentrations an order of magnitude higher. Exposure to C-60 induced both necrotic and apoptotic cellular death throughout the embryo. While C-60(OH)(24) induced an increase in embryonic cellular death, it did not induce apoptosis. Our findings concur with results obtained in other models indicating that C-60(OH)(24) is significantly less toxic than C-60. These studies also suggest that the embryonic zebrafish model is well-suited for the rapid assessment of nanomaterial toxicity. (c) 2007 Elsevier Ltd. All rights reserved.
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