Journal
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
Volume 393, Issue 4, Pages 1135-1141Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s00216-008-2521-y
Keywords
Fiber-optic nanoprobe; Intracellular pH measurement
Funding
- National Institute of Health [NIH R01 EB006201, NIH R01 ES014774]
- Department of Justice
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In this paper, we describe the development and application of a pH-sensitive plasmonics-active fiber-optic nanoprobe suitable for intracellular bioanalysis in single living human cells using surface-enhanced Raman scattering (SERS) detection. The effectiveness and usefulness of SERS-based fiber-optic nanoprobes are illustrated by measurements of intracellular pH in HMEC-15/hTERT immortalized normal human mammary epithelial cells and PC-3 human prostate cancer cells. The results indicate that fiber-optic nanoprobe insertion and interrogation provide a sensitive and selective means to monitor cellular microenvironments at the single cell level.
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