Journal
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
Volume 393, Issue 2, Pages 431-435Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s00216-008-2408-y
Keywords
Bioanalytical methods; Capillary electrophoresis; Microfluidics/microfabrication; Preconcentration; Sacrificial materials; Separations/instrumentation
Funding
- NIBIB NIH HHS [R01 EB006124, R01 EB006124-03, EB006124] Funding Source: Medline
- NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [R01EB006124] Funding Source: NIH RePORTER
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The use of polymers in microchip fabrication affords new opportunities for the development of powerful, miniaturized separation techniques. One method in particular, the use of phase-changing sacrificial layers, allows for simplified designs and many additional features to the now standard fabrication of microchips. With the possibility of adding a third dimension to the design of separation devices, various means of enhancing analysis now become possible. The application of phase-changing sacrificial layers in microchip analysis systems is discussed, both in terms of current uses and future possibilities.
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