Journal
CURRENT OPINION IN CELL BIOLOGY
Volume 19, Issue 4, Pages 436-445Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2007.04.021
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Funding
- NIDA NIH HHS [R37 DA010711-11, R37 DA010711, K02 DA000439, K02 DA000439-08] Funding Source: Medline
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Endocytosis regulates many cellular signaling processes by controlling the number of functional receptors available at the cell surface. Conversely, some signaling processes regulate the endocytic pathway. Furthermore, various cellular signaling events appear to occur on endosome membranes. The endocytic pathway, by providing a set of dynamic and biochemically specialized endomembrane structures that physically communicate with the plasma membrane, is increasingly viewed as a highly flexible scaffold for mediating precise spatiotemporal control and transport of diverse biological signals. General principles of endosome-based signaling are beginning to emerge but, in many cases, the physiological significance of signaling on the endocytic pathway remains poorly understood.
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