Journal
HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA
Volume 21, Issue 4, Pages 685-+Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.hoc.2007.06.005
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Funding
- NHLBI NIH HHS [HL-64704, R01 HL064704-05, R01 HL064704] Funding Source: Medline
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Drug-induced thrombocytopenia (DIT) is a relatively common clinical disorder. It is imperative to provide rapid identification and removal of the offending agent before clinically significant bleeding or, in the case of heparin, thrombosis occurs. DIT can be distinguished from idiopathic thrombocytopenic purpura, a bleeding disorder caused by thrombocytopenia not associated with a systemic disease, based on the history of drug ingestion or injection and laboratory findings. DIT disorders can be a consequence of decreased platelet production (bone marrow suppression) or accelerated platelet destruction (especially immune-mediated destruction).
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