Journal
CURRENT OPINION IN LIPIDOLOGY
Volume 18, Issue 4, Pages 443-450Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MOL.0b013e32823bcb15
Keywords
apolipoprotein B; atherosclerosis; foam cell emigration; regression; reverse lipid transport
Funding
- NHLBI NIH HHS [HL73898, HL56984, HL78667, HL84312, HL61814, HL38956] Funding Source: Medline
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The essential prerequisite for regression is robust improvement in plaque milieu, meaning large plasma reductions in atherogenic apolipoprotein B-lipoproteins or brisk enhancements in 'reverse' lipid transport from plaque into liver. Importantly, the processes of regression are consistent with rapid correction of features characteristic of the rupture-prone, vulnerable plaques responsible for acute coronary syndromes. New interventions to lower apolipoprotein B-lipoprotein levels and enhance reverse lipid transport may allow regression to become a widespread clinical goal. Strategies based on recent mechanistic insights may facilitate further therapeutic progress.
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