Journal
NATURE REVIEWS MICROBIOLOGY
Volume 5, Issue 8, Pages 611-618Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrmicro1708
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Funding
- Intramural NIH HHS [Z01 DK024943-14] Funding Source: Medline
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The term 'prion' means an infectious protein that does not need an accompanying nucleic acid. There are six fungal prions, including four self-propagating amyloids and two enzymes that are necessary to activate their inactive precursors. Here we explore the scope of the prion phenomenon, the biological and evolutionary roles of prions, the structural basis of the amyloid prions and the prominent role of chaperones (proteins that affect the folding of other proteins) and other cellular components in prion generation and propagation.
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