Journal
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
Volume 1773, Issue 8, Pages 1285-1298Publisher
ELSEVIER
DOI: 10.1016/j.bbamcr.2006.11.011
Keywords
gene expression; signal transduction; transcription factor; chromatin; MAP kinase; phosphorylation
Categories
Funding
- Biotechnology and Biological Sciences Research Council [C18835] Funding Source: Medline
- Medical Research Council [G0400620] Funding Source: Medline
- Wellcome Trust Funding Source: Medline
- Biotechnology and Biological Sciences Research Council [C18835] Funding Source: researchfish
- Medical Research Council [G0400620] Funding Source: researchfish
- MRC [G0400620] Funding Source: UKRI
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Mitogen-activated protein kinase (MAPK) signaling pathways are key mediators of eukaryotic transcriptional responses to extracellular signals. These pathways control gene expression in a number of ways including the phosphorylation and regulation of transcription factors, coregulatory proteins and chromatin proteins. MAPK pathways therefore target multiple components of transcriptional complexes at gene promoters and can regulate DNA binding, protein stability, cellular localization, transactivation or repression, and nucleosome structure. Recent work has uncovered further complexities in the mechanisms by which MAPKs control gene expression including their roles as integral components of transcription factor complexes and their interplay with other post-translational modification pathways. In this review I discuss these advances with particular focus on how MAPK signals are integrated by transcription factor complexes to provide specific transcriptional responses and dhow relates to cellular function. (C) 2006 Elsevier B.V. All rights reserved.
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