Journal
SCHIZOPHRENIA RESEARCH
Volume 94, Issue 1-3, Pages 317-327Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.schres.2007.03.031
Keywords
schizophrenia; MRI; cortical folding; Broca's area; language
Categories
Funding
- NCI NIH HHS [5T32 CA09502, T32 CA009502-19, T32 CA009502] Funding Source: Medline
- NCRR NIH HHS [R01 RR016594-01A1, P41 RR014075, U24 RR021382-03, P41 RR014075-08, R01 RR016594, P41-RR14075, U24 RR021382, R01 RR16594-01A1] Funding Source: Medline
- NIBIB NIH HHS [R01 EB001550, U54 EB005149] Funding Source: Medline
- NIMH NIH HHS [R01 MH071635, R01 MH067720-03, R01 MH067720] Funding Source: Medline
- NINDS NIH HHS [R01 NS052585, R01 NS052585-01, R01 NS052585-01A1] Funding Source: Medline
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We compared cortical folding patterns between patients with schizophrenia and demographically-matched healthy controls in prefrontal and temporal regions of interest. Using the Freesurfer (http://surfer.nmr.mgh.harvard.edu) cortical surface-based reconstruction methodology, we indirectly ascertained cortical displacement and convolution, together, by measuring the degree of metric distortion required to optimally register cortical folding patterns to an average template. An area within the pars triangularis of the left inferior frontal gyrus (Broca's area) showed significantly reduced metric distortion in the patient group relative to the control group (p=0.0352). We discuss these findings in relation to the neurodevelopmental hypothesis and language dysfunction in schizophrenia. (c) 2007 Elsevier B.V. All rights reserved.
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