Journal
CELL MOTILITY AND THE CYTOSKELETON
Volume 64, Issue 8, Pages 569-579Publisher
WILEY-LISS
DOI: 10.1002/cm.20211
Keywords
I1 dynein; f-dynein; cilia; flagella; axoneme
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Funding
- NIGMS NIH HHS [GM075446, GM067078, GM051173] Funding Source: Medline
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Among the major challenges in understanding ciliary and flagellar motility is to determine how the dynein motors are assembled and localized and how dynein-driven outer doublet microtubule sliding is controlled. Diverse studies, particularly in Chlamydomonas, have determined that the inner arm dynein I1 is targeted to a unique structural position and is critical for regulating the microtubule sliding required for normal ciliary/flagellar bending. As described in this review, I1 dynein offers additional opportunities to determine the principles of assembly and targeting of dyneins to cellular locations and for studying the mechanisms that regulate dynein activity and control of motility by phosphorylation.
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