Journal
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
Volume 391, Issue 6, Pages 2189-2197Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s00216-008-2145-2
Keywords
electrospun fibers; solid-phase extraction (SPE); cortisol; HPLC
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A novel fiber-packed solid-phase extraction (SPE) tip was designed based on electrospun nanofibers. The tip was used to investigate the extraction of hydrocortisone (HC), cortisone acetate (CA), ethinylestradiol (EE), and estradiol (E2). The effects of diameters, porous figurations, and functional groups of the electrospun fibers on the selectivity and efficiency were studied. The experimental results indicated that the detection limit of cortisol in water sample could be as low as 0.75 ng/mL. When the tip is used for detection of cortisol in human hair the efficiency of biological sample pretreatment is better than the traditional SPE method. Our method could significantly simplify the traditional SPE process and lower the cost. Industrial application of the tip is anticipated.
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