Journal
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
Volume 393, Issue 3, Pages 797-807Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s00216-008-2305-4
Keywords
Sample preparation; Micro-extraction; Monolithic sorbent; High throughput; Automation; Mass spectrometry; Quantitative analysis; Bioanalysis
Funding
- Department DMPK&BAC, AstraZeneca, Sodertalje, Sweden
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Analytical methods providing high throughput are required for the ever increasing number of samples in bioanalysis. Currently, the method of choice in bioanalysis is LC-MS-MS. This method is quite rapid and thereby the focus has been directed to sample preparation as being a bottleneck in total analysis systems. It has become necessary to develop sample preparation techniques to a new improved level. This development has been based on a systematic and scientific approach. The key factors in this development have been miniaturization, integration, and automation of the techniques. This review provides a short overview of recent developments. Special emphasis is on two techniques: microextraction in packed syringe (MEPS) and use of a monolithic acrylamide plug as sorbent in polypropylene tips primarily intended for use with 96-well plate systems.
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