Journal
PLOS PATHOGENS
Volume 3, Issue 8, Pages 1017-1022Publisher
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.ppat.0030108
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Funding
- NHLBI NIH HHS [P01 HL020948, HL-20948] Funding Source: Medline
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Hepatitis C virus (HCV), a single-stranded positive-sense RNA virus of the Flaviviridae family, infects more than 170 million people worldwide and is the leading cause of liver failure in the United States. A unique feature of HCV is that the viral life cycle depends on cholesterol metabolism in host cells. This review summarizes the cholesterol metabolic pathways that are required for the replication, secretion, and entry of HCV. The potential application of drugs that alter host cholesterol metabolism in treating HCV infection is also discussed.
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