Journal
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
Volume 454, Issue 5, Pages 691-702Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s00424-006-0187-x
Keywords
mechanosensitivity; sensory neurons; mechanosensitive channel; epithelial Na+ channel; TRP channel
Categories
Funding
- NIGMS NIH HHS [R37 GM030997] Funding Source: Medline
Ask authors/readers for more resources
The nematode Caenorhabditis elegans was the first organism for which touch insensitive mutants were obtained. The study of the genes defective in these mutants has led to the identification of components of a mechanosensory complex needed for specific cells to sense gentle touch to the body. Multiple approaches using genetics, cell biology, biochemistry, and electrophysiology have characterized a channel complex, containing two DEG/ ENaC pore- forming subunits and several other proteins, that transduces the touch response. Other mechanical responses, sensed by other cells using a variety of other components, are less well understood in C. elegans. Many of these other senses may use TRP channels, although DEG/ ENaC channels have also been implicated.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available