Journal
CURRENT OPINION IN CELL BIOLOGY
Volume 19, Issue 4, Pages 368-375Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2007.04.019
Keywords
-
Categories
Funding
- Telethon [GGP04129, GGP07010] Funding Source: Medline
Ask authors/readers for more resources
A large group of diverse, functionally important, and differently localized transmembrane proteins shares a particular membrane topology, consisting of a cytosolic N-terminal region, followed by a transmembrane domain close to the C-terminus. Because of their structure, these C-tail-anchored (TA) proteins must insert into all their target membranes by post-translational pathways. Recent work, based on the development of stringent and sensitive biochemical assays, has demonstrated that novel unexplored mechanisms underlie these post-translational targeting and membrane insertion pathways. Unravelling these pathways will shed light on the biosynthesis and regulation of an important group of membrane proteins and is likely to lead to new concepts in the field of membrane biogenesis.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available