Journal
PEPTIDES
Volume 28, Issue 8, Pages 1611-1614Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.peptides.2007.07.008
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Funding
- NIDDK NIH HHS [DK061956, R15 DK061956, R15 DK061956-01] Funding Source: Medline
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The prolactin secretory response to subcutaneous injection of orphanin FQ/nociceptin (OFQ/N) was measured in wild-type and OFQ/N knockout mice. These injections were given with and without isoflurane anesthesia, to determine if isoflurane would affect the prolactin secretory response. OFQ/N injection significantly increased prolactin levels in males and females, regardless of genotype, with a more robust response in females. Isoflurane pretreatment did not affect prolactin levels in controls or in animals injected with OFQ/N. This is the first report that exogenously administered OFQ/N stimulates prolactin secretion in mice and that brief isoflurane exposure does not significantly affect this response. (c) 2007 Elsevier Inc. All rights reserved.
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