Journal
CHINESE CHEMICAL LETTERS
Volume 18, Issue 8, Pages 905-908Publisher
CHINESE CHEMICAL SOC
DOI: 10.1016/j.cclet.2007.06.014
Keywords
p38 MAPK inhibitor; 1-Aryl-3-(3,4-dihydro-2H-chromen-5-yl) ureas; synthesis
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A new series of compounds, 1-aryl-3-(3,4-dihydro-2H-chromen-5-yl) ureas, have been synthesized and their structures were confirmed by FAB-MS and H-1 NMR. The preliminary pharmacological screening showed that these compounds inhibited TNF-alpha production in lipopolysaccharide (LPS)-stimulated THP-1 cells. (c) 2007 Song Li. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.
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