Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 64, Issue 16, Pages 2053-2065Publisher
SPRINGER BASEL AG
DOI: 10.1007/s00018-007-7008-z
Keywords
angiogenesis; RhoA; Rac1; Cdc42; endothelial cell
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The members of the Rho family of small GTPases are involved in an array of cellular processes, including regulation of the actin cytoskeleton, cell polarity, microtubule dynamics, membrane transport, and transcription factor activity. Recent findings have implicated the Rho-proteins as key regulators of angiogenesis, modulating a diversity of cellular processes, including vascular permeability, extracellular matrix remodeling, migration, proliferation, morphogenesis, and survival.
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