4.8 Article

A rapid synthesis of the biotin core through a tandem michael reaction

Journal

ORGANIC LETTERS
Volume 9, Issue 16, Pages 2973-2975

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol0710663

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A biotin core has been assembled in a short and efficient sequence utilizing a tandem intramolecular Michael reaction/fragmentation/Michael reaction from vinyl sulfoxide and sulfone alcohols (12 and 13).

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