Journal
ANALYTICA CHIMICA ACTA
Volume 831, Issue -, Pages 50-59Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.aca.2014.04.061
Keywords
Electrochemical sensor; Chemically modified carbon paste electrode; Magnetic nanoparticles; Graphene; Simultaneous determination of tramadol and acetaminophen
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Funding
- Bu-Ali Sina University Research Council
- Center of Excellence in Development of Environmentally Friendly Methods for Chemical Synthesis (CEDEFMCS)
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An effective electrochemical sensor for the rapid and simultaneous determination of tramadol and acetaminophen based on carbon paste electrode (CPE) modified with NiFe2O4/graphene nanoparticles was developed. The structures of the synthesized NiFe2O4/graphene nanocomposite and the electrode composition were confirmed by X-ray diffraction (XRD) spectrometry, Fourier transform infrared (FT-IR) spectrometry and scanning electron microscopy (SEM). The peak currents of square wave voltammetry of tramadol and acetaminophen increased linearly with their concentration in the range of 0.01-9 mu mol L (1). The detection limit for their determination was found to be 0.0036 and 0.0030 mu mol L (1), respectively. The results show that the combination of graphene and NiFe2O4 nanoparticles causes a dramatic enhancement in the sensitivity of the sensor. The fabricated sensor exhibited high sensitivity and good stability, and would be valuable for the clinical assay of tramadol and acetaminophen. (C) 2014 Elsevier B.V. All rights reserved.
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