Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 72, Issue 16, Pages 5968-5972Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jo070411z
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Funding
- NCI NIH HHS [5R44 CA 096020-03] Funding Source: Medline
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We describe the development of methodology which allows for the introduction of a second disulfide bond into a molecular framework with a pre-existing disulfide linker system. Compounds which contain an S-9-fluorenylmethyl-protected thiol and an additional disulfide linkage are deprotected in situ and trapped with an activated thiophile. This methodology allowed for the synthesis of the first molecule possessing two different biologically active agents covalently attached to a folate receptor targeting ligand unit via two disulfide-based release systems.
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