Journal
ANALYTICA CHIMICA ACTA
Volume 806, Issue -, Pages 74-84Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.aca.2013.10.053
Keywords
Ultrasound; Sample preparation; Metabolomics; Metallomics; Lipidomics; Xenometabolomics
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Funding
- Spanish Ministerio de Economia y Competitividad (MEC)
- FEDER program [CTQ2012-37428]
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Metabolomics, one of the most recently emerged omics, has taken advantage of ultrasound (US) to improve sample preparation (SP) steps. The metabolomics-US assisted SP step binomial has experienced a dissimilar development that has depended on the area (vegetal or animal) and the SP step. Thus, vegetal metabolomics and US assisted leaching has received the greater attention (encompassing subdisciplines such as metallomics, xenometabolomics and, mainly, lipidomics), but also liquid-liquid extraction and (bio)chemical reactions in metabolomics have taken advantage of US energy. Also clinical and animal samples have benefited from US assisted SP in metabolomics studies but in a lesser extension. The main effects of US have been shortening of the time required for the given step, and/or increase of its efficiency or availability for automation; nevertheless, attention paid to potential degradation caused by US has been scant or nil. Achievements and weak points of the metabolomics-US assisted SP step binomial are discussed and possible solutions to the present shortcomings are exposed. (C) 2013 Elsevier B.V. All rights reserved.
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