Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 104, Issue 32, Pages 12994-12998Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0705250104
Keywords
antibiotic; Candida albicans; matrix
Categories
Funding
- NIDCR NIH HHS [DE017846, R44 DE017846, R43 DE017846] Funding Source: Medline
- NIGMS NIH HHS [R01 GM035010, GM073626, R01 GM073626, GM035010] Funding Source: Medline
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Fungi are increasingly identified as major pathogens in bloodstream infections, often involving indwelling devices. Materials with antifungal properties may provide an important deterrent to these infections. Here we describe amphogel, a dextran-based hydrogel into which amphotericin B is adsorbed. Amphogel kills fungi within 2 h of contact and can be reused for at least 53 days without losing its effectiveness against Candida albicans. The antifungal material is biocompatible in vivo and does not cause hemolysis in human blood. Amphogel inoculated with C albicans and implanted in mice prevents fungal infection. Amphogel also mitigates fungal biofilm formation. An antifungal matrix with these properties could be used to coat a variety of medical devices such as catheters as well as industrial surfaces.
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