Journal
FEBS LETTERS
Volume 581, Issue 20, Pages 3783-3788Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2007.06.076
Keywords
histone H1; histone H1.X; chromosome; RNAi; FRAP; mitosis
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We report here the characterization of H1.X, a human histone H1 subtype. We demonstrate that H1.X accumulates in the nucleolus during interphase and is distributed at the chromosome periphery during mitosis. In addition, the results of fluorescence recovery after photobleaching indicate that the exchange of H1.X on and off chromatin is faster than that of the other HI subtypes. Furthermore, RNA interference experiments reveal that H1.X is required for chromosome alignment and segregation. Our results suggest that H1.X has important functions in mitotic progression, which are different from those of the other HI subtypes. (c) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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