Journal
FEBS LETTERS
Volume 581, Issue 20, Pages 3857-3862Publisher
WILEY
DOI: 10.1016/j.febslet.2007.07.012
Keywords
iNOS; nitric oxide; colon cancer; microvasculature
Funding
- NCI NIH HHS [R03 CA119261, R01CA109861, R01 CA109861, U01CA111257, U01 CA111257, R03CA119261, U01 CA111257-04] Funding Source: Medline
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We have recently demonstrated that dramatic alteration in mucosal microvascular blood content termed early increase in blood supply (EIBS) is a hallmark of early colon carcinogenesis. In the current study, we elucidate the mechanism of FIBS by assessing iNOS/nitric oxide axis in the histologically normal colonic mucosa of rats treated with the colon-specific carcinogen, azoxymethane. We demonstrate that there was a strong temporal correlation between FIBS and iNOS expression/activity. Importantly, we also observed that short-term treatment with nitric oxide inhibitor abrogated EIBS. These data indicate that iNOS induction may have a critical role in augmenting the predysplastic mucosal blood supply and thereby fostering colon carcinogenesis. (c) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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