Journal
CANCER LETTERS
Volume 253, Issue 1, Pages 144-153Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2007.01.024
Keywords
ovarian carcinoma; CD4(+)CD25(+) regulatory T cell; Foxp3; TGF-beta
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Increased CD4(+)CD25(+) regulatory T cells predicted poor prognosis in ovarian carcinoma patients. This study aimed to define whether soluble substances secreted by ovarian carcinoma could up-regulate the proportion of CD4(+)CD25(+), regulatory T cells. Similar to TGF-P, the low MWF (<50 kDa) of supernatant derived from SKOV3 could convert part of freshly isolated CD4(+)CD25(-) T cells into CD25(+) population with similar characters as natural CD4+CD25+ regulatory T cells. To deplete TGF-P in the low MWF by neutralizing anti-TGF-P would eliminate this transformation phenomenon. These results indicate that TGF-P secreted by ovarian carcinoma cells owns vital function in the process of converting peripheral CD4+CD25- T cells into CD4+CD25+ regulatory T cells, which may provide one immunotherapeutic target for ovarian cancer. (C) 2007 Elsevier Ireland Ltd. All rights reserved.
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